Levodopa administration modulates striatal processing of punishment-associated items in healthy participants.

Citation:
Wittmann, BC, D'Esposito M.  2014.  Levodopa administration modulates striatal processing of punishment-associated items in healthy participants., 2014 Jun 13. Psychopharmacology.

Abstract:

Appetitive and aversive processes share a number of features such as their relevance for action and learning. On a neural level, reward and its predictors are associated with increased firing of dopaminergic neurons, whereas punishment processing has been linked to the serotonergic system and to decreases in dopamine transmission. Recent data indicate, however, that the dopaminergic system also responds to aversive stimuli and associated actions.